下川哲昭

学位

医学博士(群馬大学)

 

略歴

1990年 群馬大学 大学院医学系研究科 (生理学系内分泌学専攻) 博士課程 修了

1990年 (特)理化学研究所 奨励研究員 (真核生物研究室) 

1991年 静岡県立大学 大学院健康科学研究科 助手 (代謝調節学研究室) 

1994年 群馬大学 医学部 助手 (第一生理学教室)

1997年 群馬大学 医学部 講師 (第一生理学教室)

2000年 文部科学省 在外研究員 (スウェーデン・ルードヴィック癌研究所)

2004年 群馬大学 大学院医学系研究科 助教授 (応用生理学分野)

2014年 高崎健康福祉大学 健康福祉学部 教授 (健康栄養学科)

 

専門分野

神経内分泌学・栄養生理学

 

主な担当科目

解剖生理学・生物学

 

所属学会

日本生理学会・日本生化学会・日本内分泌撹乱化学物質学会・北関東医学会会員

 

学術活動

Editorial Board Member, Endocrinology and Metabolic Syndrome,  USA

Advisory Board Member, OA Biochemistry, OA Publishing London, UK

Editorial Board Member, Biomedical Reports, Spandidos Publications, Greece

Editorial Board Member, Oncology Reports, Spandidos Publications, Greece

Editorial Board Member, Hormonal Studies, Herbert Publications, UK

 

研究業績(最近5年間)

<著書>

1. Receptor Tyrosine Kinases (Germano, S.,  ed.) Downregulation of receptor tyrosine kinases through ubiquitination: analysis by Immunodetection.pp. 121-133, 2014Humana Press.

2. リッピンコット・生理学 (栗原、鯉淵 監訳) 第36章「男性および女性の生殖系」、 第37章「妊娠と出産」pp. 513-543. 2014, 丸善出版

3.  内分泌・栄養・代謝系コア・カリキュラムテキスト  (寺内、鯉淵、後藤 編集) 「性ホルモンの合成・代謝経路と作用」 pp.48-53, 2011, 文光堂

<学術論文>

1. Shimokawa N, Haglund K, Hölter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londoño MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher WS, Wolfer PD, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, Harbé de Angelis M, Dikic I. CIN85 regulates dopamine receptor endocytosis and governs behavior in mice. EMBO J, 29, 2421-2432, 2010.

2. Londoño MB, Shimokawa N, Miyazaki W, Iwasaki T, Koibuchi N. Hydroxylated PCB induces Ca2+ oscillations and alterations of membrane potential in cultured cortical cells. J. Appl. Toxicol. 30, 334-342, 2010.

3. Amano I, Miyazaki W, Iwasaki T, Shimokawa N, Koibuchi N. The effect of hydroxylated PCB metabolites on TR-mediated transcription through native-TRE. Ind. Health 48, 115-118, 2010

4. Ibhazehiebo K, Iwasaki T, Kimura-Kurods J, Miyazaki W, Shimokawa N, Koibuchi N. Disruption of thyroid hormone receptor-mediated transcription and thyroid hormone-induced Purkinje cell dendrite arborization by polybrominated diphenylethers. Environ. Health Perspect. 119, 168-75, 2011.

5. Ibhazehiebo K, Iwasaki T, Shimokawa N, Koibuchi N. 1,2,5,6,9,10- αHexabromocyclododecane (HBCD) impairs thyroid hormone-induced dendrite arborization of Purkinje cells and suppresses thyroid hormone receptor-mediated transcription. Cerebellum 10, 22-31, 2011.

6. Ibhazehiebo K, Iwasaki T, Xu M, Shimokawa N, Koibuchi N. Brain-derived neurotrophic factor (BDNF) ameliorates the suppression of thyroid hormone-induced granule cell neurite extension by hexabromocyclododecane (HBCD). Neurosci. Lett. 493, 1-7, 2011.

7. Ibhazehiebo K, Iwasaki T, Okano-Uchida T, Shimokawa N, Ishizaki Y, Koibuchi N. Suppression of thyroid hormone receptor-mediated transcription and disruption of thyroid hormone-induced cerebellar morphogenesis by the polybrominated biphenyl mixture, BP-6. Neurotoxicology 32, 400-409, 2011.

8. Takahashi Y, Shimokawa N, Esmaeili-Mahani S, Morita A, Masuda H, Iwasaki T, Tamura J, Haglund K, Koibuchi N. Ligand-induced downregulation of TrkA is partly regulated through ubiquitination by Cbl. FEBS Lett. 585, 1741-1747, 2011.

9. Itoh M, Shimokawa N, Tajika Y, Murakami T, Aotsuka N, Lesmana R, Farenia R, Iwasaki T, Okada J, Yorifuji H, Koibuchi N. Alterations of biochemical marker levels and myonuclear numbers in rat skeletal muscle after ischemia-reperfusion. Mol. Cell. Biochem. 373, 11-18, 2013.

10. Takatsuru Y, Eto K, Kaneko R, Masuda H, Shimokawa N, Koibuchi N, Nabekura J. Critical role of the astrocyte for functional remodeling in contralateral hemisphere of somatosensory cortex after stroke. J. Neurosci. 33, 4683-4692, 2013.

11. Hirooka-Masui K, Lesmana R, Iwasaki T, Xu M, Hayasaka K, Haraguchi M, Takeshita A, Shimokawa N, Yamamoto K, Koibuchi N. Interaction of silencing mediator for retinoid and thyroid receptors with steroid and xenobiotic receptor on multidrug resistance 1 promoter. Life Sci. 92, 911-915, 2013.

12. Xu M, Sulkowski ZL, Parekh P, Khan A, Chen T, Midha S, Iwasaki T, Shimokawa N, Koibuchi N, Zavacki AM, Sajdel-Sulkowska EM. Effects of Perinatal Lipopolysaccharide (LPS) Exposure on the Developing Rat Brain; Modeling the Effect of Maternal Infection on the Developing Human CNS. Cerebellum 12, 572-586, 2013.

13. Xu M, Iwasaki T, Shimokawa N, Sajdel-Sulkowska EM, Koibuchi N. The effect of low dose lipopolysaccharide on thyroid hormone-regulated actin cytoskeleton modulation and type 2 iodothyronine deiodinase activity in astrocytes. Endocr. J., in press, 2013.

14. Lesmana R, Shimokawa N, Takatsuru Y, Iwasaki T, Koibuchi N. Lactational exposure to hydroxylated polychlorinated biphenyl (OH-PCB 106) causes hyperactivity in male rat pups by aberrant increase in dopamine and its receptor. Environ. Toxicol. 29, 876-883, 2014.

15. Ichinose T, Lesmana R, Yamamoto A, Kobayashi T, Shitara F, Shimoyama D, Yusuke Takatsuru Y, Iwasaki1 T, Shimokawa T, Takagishi K, Koibuchhi N. Possible involvement of IGF-1 signaling on compensatory growth of the infraspinatus muscle induced by the supraspinatus tendon detachment of rat shoulder. Physiological Report 2, e00197, doi: 10.1002/phy2.197, 2014.

16. Shimokawa N, Yousefi B, Morioka S, Yamaguchi S, Ohsawa A, Hayashi H, Azuma A, Mizuno H, Furudate S, Haijima A, Takatsuru Y, Iwasaki T, Umezu M,Koibuchi N. Altered cerebellum development and dopamine distribution in a rat genetic model with congenital hypothyroidism. J. Neuroendocrinol. 26, 164-175, 2014.

17. ToyaS, Takatsuru Y, Amano I, Shimokawa N, Koibuchi N. Early-life-stress affects the homeostasis of glutamatergic synapses. E. J. Neurosci., in press, 2014.